Effects of Buyang Huanwu Decoction and Radix Astragali On Astrocytes in Gerbils with Cerebral Ischemia and Reperfusion Injury
- VernacularTitle:补阳还五汤和黄芪对脑缺血再灌注后星形胶质细胞的影响
- Author:
Zhen LAI
;
Shayan WANG
;
Changqing DENG
;
Xiaoyin GENG
;
Ruanzhang ZHANG
- Publication Type:Journal Article
- Keywords:
BUYANG HUANWU DECOCTION/pharmacology;
RADIX ASTRAGALI/pharmacology;
CEREBRAL ISCHEMIA /TCD therapy;
ASTROCYTES;
GERBILS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
1999;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To study the effects of Buyang Huanwu Decoction and Radix Astragali on astrocytes in gerbils with cerebral ischemia and reperfusion injury. [Methods] Gerbils model of cerebral ischemia was set up by occlusion of bilateral common carotid arteries. The dynamic expression of glial fibrillary acidic protein (GFAP) were determined by immunohistochemical method in reperfusion for 24 and 48 hours after 15 minutes of cerebral ischemia. [Results] Positive expression of GFAP reached a peak in reperfusion for 24 hours and was decreased by Buyang Huanwu Decoction and Radix Astragali. Positive GFAP expression was attenuated in reperfusion for 48 hours and enhanced by Buyang Huanwu Decoction and Radix Astragali increased the expression. [ Conclusion ] The regulatory effect of Buyang Huanwu Decoction and Radix Astragali on astrocytes may be one of its mechanisms in repairing nervous function after cerebral ischemia.
