MORPHOLOGY REMODELING OF ARTERIAL ENDOTHELIUM INFLUENCED BY FLOW SHEAR STRESS in vivo
- VernacularTitle:血流切应力影响动脉内皮形态重建的在体研究
- Author:
Weijun CHEN
;
Dajun YING
- Publication Type:Journal Article
- Keywords:
Shear stress;
Artery;
Endothelial cell;
Morphology;
Remodeling
- From:
Acta Anatomica Sinica
1955;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of wall shear stress(WSS) effect on endothelial cell morphology remodeling after reducing arterial flow. Methods The reducing flow of common carotid artery was established in 60 rabbits,and arterial stretched preparations were made at 8 different intervals from 0 to 30 days.The shape and fibrous actin(F-actin)of arterial endothelial cell(AEC)were observed under an microscope and confocal laser scanning microscope(CLSM) using silver and fluorescein-phalloidin stain. Results The fewer stress fibers were viewed in AEC and its shape changed from spindle to ellipse after WSS decreased for 12 hours,the value of shape index(SI) and length/width(L/W) was greatly higher and lower than the levels of control,respectively(P
