EXPRESSION OF E-CADHERIN/CATENIN COMPLEX ON HUMAN NON-SMALL CELL LUNG CARCINOMA CELL LINES
- VernacularTitle:E钙粘蛋白/catenin复合体在人非小细胞肺癌细胞系中的表达
- Author:
Jing LI
;
Yu LI
;
Wuru WANG
- Publication Type:Journal Article
- Keywords:
Non-small cell lung carcinoma;
E-cadherin;
catenins
- From:
Acta Anatomica Sinica
1955;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the involvement of the E-cadherin-catenin adhesion system in the progression of human non-small cell lung carcinoma cell lines. Methods Expression of E-cadherin, alpha-catenin, and beta-catenin in seven human lung carcinoma cell lines were studied with immunocytochemistry and RT-PCR. Results Abnormal expression of at least one component of the E-cadherin/catenin complex was seen in each non-small cell lung carcinoma cell line.Conclusion The abnormal expression of E-cadherin, alpha-catenin, and beta-catenin was closely related with the occurrence of lung carcinomas.
