The Clinical efficacy in the treatment of early diabetic nephropathy from rosuvastatin combined with benaze-pril
10.3760/cma.j.issn.1008-6706.2014.14.021
- VernacularTitle:瑞舒伐他汀联合贝那普利治疗早期糖尿病肾病疗效观察
- Author:
Li DIAO
;
Jianmei SUN
- Publication Type:Journal Article
- Keywords:
Diabetic nephropathy;
Rosuvastatin;
Benazepril
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(14):2130-2131,2132
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical efficacy in the treatment of early diabetic nephropathy from ro-suvastatin combined with benazepril .Methods 107 patients of early diabetic nephropathy in our hospital were retro-spectively analyzed .On the basis of the conventional treatment of diabetes ,the control group were treated with benaze-pril;while the observation group were treated with rosuvastatin combined with benazepril .Before and after treatment , the improvement of the related indicators were observed , such as blood glucose ,lipids and renal function .The clinical efficacy were comprehensively evaluated .Results The level of the fasting blood glucose and 2-hour postprandial blood glucose of the observation group were lower than those of the control group , the difference was significant ( t=9.785,9.525,all P<0.05);the blood lipid levels such as TC ,TG and LDL-C in the observation group were signifi-cantly lower than those of the control group .But the levels of HDL-c was significantly increased , the difference was significant(t=9.938,10.283,10.475,9.782,allP<0.05);the indicators of renal function such as UAER ,Scr and BUN were significantly lower than those of the control group , the difference was significant ( t =9.938,12.341, 11.265,9.982,all P<0.05);The total effective rate of the observation group was 94.55%,significantly higher than the 76.92%of the control group, the difference was statistically significant (χ2 =10.120,P<0.05).Conclusion The effect of rosuvastatin combined with benazepril for the treatment of early diabetic nephropathy is very significant which is worthy applying in clinical practice .
