Analysis of the clinical efficacy and safety of intravenous sequential oral voriconazole treatment of blood dis-eases combined invasive fungal infections
10.3760/cma.j.issn.1008-6706.2014.14.009
- VernacularTitle:静脉序贯口服伏立康唑治疗血液病患者合并侵袭性真菌感染疗效和安全性分析
- Author:
Guowei CHAI
- Publication Type:Journal Article
- Keywords:
Voriconazole;
Blood diseases;
Infection;
Fungi
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(14):2102-2103,2104
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy and security of intravenous sequential oral voricon -azole treatment of blood diseases combined invasive fungal infections (IFI).Methods Combined blood of patients were reated with invasive fungal infections ,88 patients were randomly divided into the control group and treatment group using sequential treatment , the control group were treated with conventional anti-infective therapy , treatment group based on the use of conventional anti-infective drugs ,plus implementation of voriconazole therapy .The clinical efficacy were compared and adverse drug reactions were observed .Results The total effective rate of the treatment group was 90.91%,which was significantly higher than 70.45%of the control group (χ2 =5.906,P<0.05);the in-fection control in patients treated with time ,continuous medication and incidence of adverse events of the treatment group were significantly lower than those of the control group (t=2.019,P<0.05;t=1.987,P<0.05;χ2 =4.062, P<0.05).Conclusion Intravenous sequential oral voriconazole therapy combined blood invasive fungal infections in patients is safe ,effective,fewer adverse reactions ,which is widely used clinically .
