Effect of rosiglitazone on insulin resistance and hyperandrogenism in polycystic ovary syndrome
- VernacularTitle:罗格列酮对多囊卵巢综合征胰岛素抵抗及高雄激素血症的治疗研究
- Author:
Zhiqun ZHENG
;
Meizhi LI
;
Yichuan LIN
;
Yanhui MA
- Publication Type:Journal Article
- Keywords:
Polycystic ovary syndrome;
Insulin resistance;
Hyperandrogenism;
Thiazoles;
Leptin;
Ovulation
- From:
Chinese Journal of Obstetrics and Gynecology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of rosiglitazone on insulin resistance and hyperandrogenism in polycystic ovary syndrome (PCOS) Methods Rosiglitazone was given 4 mg daily to 30 patients with PCOS for 12 weeks Before and after treatment, body mass index(BMI), plasma glucose, insulin, levels insulin resistance index (HOMA IR), blood lipid spectrum, leptin, neuropeptide Y, and sex hormone concentrations and ovulation rate were determined and compared Results After 12 weeks of treatment, basal insulin level decreased from (18?8) to (12?7) mIU/L ( P
