The role of Fas/FasL expression caused by H.pylori in gastric adenocarcinoma.
- VernacularTitle:幽门螺杆菌感染对Fas/FasL表达的影响在胃癌发生中的作用
- Author:
Zongwen BAN
;
Zongshun LU
;
Xueyan YAN
- Publication Type:Journal Article
- Keywords:
H.pylori;
Gastric cancer;
Pathogenesis
- From:
Chinese Journal of Digestion
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of different H.pylori strains (cagA + and cagA -) infection on Fas/FasL expression and the pathogenesis of gastirc carcinoma. Methods Gastric biopsy specimens were taken from 80 patients, and these patients were divided into 9 groups according to the H E staining and H.pylori infection. H.pylori (+) groups were subdivided into cagA + and cagA - groups. RUT, PCR and histology were used to detect H.pylori and PCR for cagA detection. Immunohistochemical staining was used to detect Fas/FasL expression. Results The infection rate of H.pylori was 60.0%, and rate of cagA(+) is 90.47%. H.pylori (+) specimens express Fas/FasL more higher than H.poylori (-) ones ( P 0.05). Conclusions Our data suggest that H.pylori infection can induce the expression of Fas/FasL in gastric epithelial cells. Gastric adenocarcinoma express high amount of FasL, which may plays an important role in immune escape of stomach cancer.
