Expression of bFGF and its effect on tumor interstitial angiogenesis and progression in gastric carcinoma
- VernacularTitle:胃癌组织碱性成纤维细胞生长因子表达及对血管新生和肿瘤进展的影响
- Author:
Xin GUO
;
Yulin LI
;
Lihong ZHANG
- Publication Type:Journal Article
- Keywords:
Gastric carcinoma;
Basic fibroblast growth factor;
Angiogenesis;
Immunohistochemistry
- From:
Chinese Journal of Digestion
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective The purpose of this study was to investigate the expression of basic fibroblast growth factor (bFGF) and its effect on tumor interstitial angiogenesis and the biological behavior of gastric carcinoma. Methods CD34 was used to explore the microvessel density (MVD) as the marker of endothelial cell. bFGF was qualitatively and quantitatively detected with immunohistochemistry on 74 cases of gastric carcinoma and 17 cases of adjacent normal gastric tissue. Results Measurement of CD34 expression could be used to describe endothelial cell proliferation and vascularity. Strong expression of bFGF was localized in the cytoplasm of tumor cell and interstitial new microvessel endothelial cells. Expression of bFGF in tumor tissue was stronger than in corresponding non tumor normal gastric tissue ( P
