Detection of telomerase activity in the specimen lung nodules through CT-guided percutaneous transthoracic needling biopsy
- VernacularTitle:CT引导下经皮肺穿刺活检物端粒酶活性检测
- Author:
Yiping ZHUANG
;
Jin ZHANG
;
Jun YU
- Publication Type:Journal Article
- Keywords:
Telomerase;
Computed tomography;
Biopsy, needle;
Nodule, lung
- From:
Journal of Interventional Radiology
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To invstigate the diagnostic value of the detection of telomerase activity in the specimen obtained from CT guided percutaneous transthoracic needle biopsy of lung nodules.Methods The techniques of TRAP silver staining were performed to detect telomerase activity in 43 cases. Results 43 mass cases were studied includirg 32 proved to be primary lung cancer, and 11 benign lesions cytologically and clinically. Telomerase activity was detected as 28(87.5%) of 32 lung carcinomas, whereas in benign lung lesions was 1(9.1%) in 11 cases.Conclusions Detection of telomerase activity in the specimen of lung nodules by CT guided percutaneous transthoracic needle biopsy may be an effective method in the diagnosis of lung cancer and also as tumor marker.
