Pharmacodynamics of Xueminning Granule on hemorrhage of upper digestive tract
- VernacularTitle:血敏宁颗粒治疗上消化道出血的药效学实验研究
- Author:
Liping HU
;
Xiaomei HUANG
;
Xiuping ZHAO
;
Huiying ZHANG
;
Jie MA
;
Pumi WANG
- Publication Type:Journal Article
- Keywords:
Xueminning Granule;
hemorrhage of upper digestive tract;
pharmacodynamics
- From:
Chinese Traditional Patent Medicine
1992;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the pharmacodynamics of Xueminning Granule (XG) on hemorrhage of upper digestive tract.Methods:Applying pylorus-ligated stomach ulcer model on rats; gastric mucosa injury induced by absolute ethy1 alcohol on rats and stomach ulcer induced by reserpine on mice to investigate the stomach ulcer-preventive effects of XG; applying the gastric juice analysis to investigate the mechanism of XG;applying the coagulation time test and bleeding time test and platelet count on mice to investigate the hemostatic effects of XG. Results: obviously prophylactico-therapeutic effects on three stomach ulcer model were found; the ulcer index and gastric juice output were decreased; the coagulation time and bleeding time were shortened.Conclusion:pharmacodynamics basis of XG on hemorrhage of upper digestive tract were provided.
