Immunohistochemical study of Fas/FasL expression in the salivary glands of patients with primary Sjgren′s syndrome
- VernacularTitle:干燥综合征唇腺组织Fas FasL表达的免疫组织化学研究
- Author:
Xiaoli LIU
;
Xiaoqin ZHANG
;
Bing LIU
- Publication Type:Journal Article
- Keywords:
Sjgren′s syndrome;
Immunohistochemistry;
Salivary gland;
Antigens,CD95;
Membrane glycoproteins
- From:
Chinese Journal of Rheumatology
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the location and expression of Fas/FasL in the salivary glands of patients with primary Sjgren′s syndrome (SS).Methods Expression of Fas and Fas ligand (FasL) in salivary gland biopsy material was detected in situ by immunohistochemical technique.Results Fas/FasL were strongly expressed in the acinar and ductal epithelial cells in SS.In contrast,few Fas/FasL were expressed in the salivary glands of normal subjects.The majority of infiltrating lymphocytes in SS did not express Fas/FasL.The number of infiltrating lymphocytes area was not associated with the acinar and ductal epithelial cells in SS.Conclusion These results suggest that the expression of Fas/FasL in the acinar and ductal epithelial cells may be an important mechanism leading to the glandular destruction found in SS.
