DISTRIBUTION OF ESTROGEN RECEPTOR-? IMMUNOREACTIVITY IN THE BRAIN OF ADULT FEMALE RATS
- VernacularTitle:雌激素 ?受体免疫阳性神经元在成年雌性大鼠脑内的分布
- Author:
Jiqing ZHANG
;
Wenqin CAI
- Publication Type:Journal Article
- Keywords:
Estrogen receptor beta;
Brain;
Immunocytochemistry;
Rat
- From:
Acta Anatomica Sinica
1954;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective Studies have shown that estrogen plays profound roles on nerve system,but the mechanism is now poorly understood.In order to address this question,the distribution of the newly cloned estrogen receptor ?(ER\|?) immunoreactivity(ER\|?\|ir) was examined in the brain of adult female rats. Methods Using nickel ammonium sulfate intensified immunohistochemistry technique. Results 1.ER\|?\|ir was mainly localized in the nuclei of neurons,it was also found in the perikaryon and neuritis;while in very few neurons,positive signals were only detected in the perikaryon and neuritis;2.High level of ER\|?\|ir positive signals were detected in the anterior olfactory nucleus,cerebral cortex,Purkinje cells,vertical limb of the diagonal band,superior vestibular nucleus,endopiriform nucleus,lateral amygdaloid nucleus,red nucleus and loci ceruleus;moderate level of ER\|?\|ir was detected in the medial septal nucleus,posterior cortical nucleus of the amygdaloid,CA3 and CA4 of the hippocampus,dentate gyrus,bed nucleus of the stria terminalis,supraoptic nucleus;weak signals were detected in the nuclei of hypothalamus,oculomotor nucleus,claustrum and some nuclei of the amygdaloid complex.Conclusion\ ER\|? immunoreactive neurons are extensively distributed in the brain of the adult female rats;this receptor may be involved in different brain function in different brain nuclei. \;[
