Expression of Dishevelled protein is correlated with the proliferation and invasion of glioma
10.3760/cma.j.issn.1006-9801.2014.04.011
- VernacularTitle:Dishevelled蛋白表达与脑胶质瘤增殖、侵袭的相关性研究
- Author:
Jian LI
;
Geng GUO
;
Yimin FAN
;
Jiehe HAO
;
Jin LI
- Publication Type:Journal Article
- Keywords:
Glioma;
Protein,dishevelled;
Tumor proliferation;
Neoplasm invasiveness
- From:
Cancer Research and Clinic
2014;26(4):250-252,256
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between Dishevelled protein expression and the proliferation and invasion of glioma cells.Methods 67 cases of brain glioma specimens were collected.The expression of Dishevelled protein was detected with immunohistochemical method.The immunoreactivity score (IRS) of Dishevelled protein,and proliferation index (PⅠ) and invasion index (Ⅱ) were measured and their correlations were analyzed.Results The positive rate of Dishevelled protein in glioma was 65.7 ％ (44/67).IRS,PⅠ and Ⅱ were 4.15±3.13,(30.93±17.92) ％,(20.38±13.36) ％,respectively.Both PⅠ and Ⅱ significantly increased with an increase in the pathological grade of brain glioma (P ＜ 0.001).Furthermore,PⅠ and Ⅱ were significantly higher in the Dishevelled protein-positive group than those in the Dishevelled protein-negative group [(38.27±17.60) ％ vs (16.02±8.92) ％ of PⅠ and (30.03±13.81) ％ vs (10.63±4.41) ％ of Ⅱ,respectively,P ＜ 0.001].PⅠ and Ⅱ of glioma cells were positively correlated with IRS of Dishevelled protein (r =0.940 between PⅠ and IRS,and r =0.953 between Ⅱ and IRS,respectively).Conclusion Dishevelled protein plays an important role in the proliferation and invasion of brain malignant glioma.
