THE EXPRESSIONS OF VCAM-1 AND MHC CLASSⅡ MOLECULES IN THE EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS RAT BRAIN VASCULAR ENDOTHELIAL CELLS
- VernacularTitle:自身免疫性脑脊髓炎大鼠脑血管内皮细胞VCAM-1和MHCⅡ类分子表达
- Author:
Hongyan LIU
;
Guizhen YANG
- Publication Type:Journal Article
- Keywords:
Vascular cell adhesion molecule\|1(VCAM\|1);
Major histocompatibility complex class Ⅱ molecules (MHC class Ⅱ molecules);
Experimental autoimmune encephalomyelitis(EAE);
Rat
- From:
Acta Anatomica Sinica
1954;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the surface molecule changes of the experimental autoimmune encephalomyelitis (EAE) rat brain vascular endothelial cells. Methods The expressions of vascular cell adhesion molecule\|1(VCAM\|1) and major histocompatibility complex (MHC) class Ⅱ molecules in the EAE rat brain vascular endothelial cells were tested by immunohistochemistry. The level of tumor necrosis factor (TNF) and interferon\|?(IFN\|?) in defferent clinic grade EAE were tested by MTT [3\|(4 5\|dimethythiazol\|zyl)\|2\^5\|diphenyl) tetrazolium bromide] method. Results There were inducible expressions of VCAM\|1 and MHC class Ⅱ molecules in the EAE rat brain vascular endothelial cells compared with control. The sera of EAE rats possessed the activities of TNF and IFN\|?.Conclusion\ In the CNS inflammation, the change surface molecules in the brain vascular endothelial cells may suggest that it plays important roles in EAE pathogenesis.\;[
