Relationship between genetic polymorphisms of cytochrome P450 2E1 and gastric cancer
- VernacularTitle:细胞色素P450 2E1基因与胃癌易感性关系
- Author:
Qiuhong ZHENG
;
Fusheng GONG
;
Yunqing XIE
- Publication Type:Journal Article
- Keywords:
Cytochrome P450 2E1;
Gastric cancer;
Gene polymorphism;
Susceptibility
- From:
Chinese Journal of Digestion
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between genetic polymorphisms of cytochrome P450 2E1(CYP2E1) and susceptibility to gastric cancer. Methods Genotype of CYP2E1 was determined by polymorphism (PCR-RFLP) analysis on DNA in 92 patients with gastric cancer and 92 controls in case-control study. Results The results showed that the frequency of the wild-type genotype (C1/C1) detected by RsaⅠ digestion was 66.3% and 48.9% in gastric cancer group and controls, respectively (P
