Pharmacodynamic Study of Bao Xin Kang in Rabbits with Cardiac Insufficiency
- VernacularTitle:保心康对家兔实验性心功能不全动物模型的药效学研究
- Author:
Yupeng CHEN
;
Shaoxiang XIAN
;
Yanshou HUANG
- Publication Type:Journal Article
- Keywords:
HEART FAILURE,CONGESTTVE/TCD therapy;
BAO XIN KANG/pharmacology;
BLOOD RHEOLOGY;
NITRIC OXIDE;
DISEASE MODEL, ANIMAL;
RABBITS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To study the pharrnacodynamic effect of Bao Xin Kang on animal models with cardiac insufficiency (CI) . [Methods] CI animal models were established by constricting the abdominal aortae in rabbits. The pathological results in different groups were compared. The hemodynamics indices such as LVEDP and?dp/dtmax and NO level were measured. [Results] Compared with the model group, the high dose of Bao Xin Kang can lessen the hyperplasia and hypertrophy of the myocardium and relieve the pulmonary edema in animals and improve the hemodynamics indices. LVEDP was decreased ( P
