Selective Inhibitory Effect of Sinomenine on Activity of Cyclooxygenase 2
- VernacularTitle:青藤碱对环氧化酶2活性的选择性抑制作用
- Author:
Wenjun WANG
;
Peixun WANG
- Publication Type:Journal Article
- Keywords:
CAULIS SINOMEN I/pharmacology;
SINOMENINE /pharmacology;
INFLAMMATION/TCD therapy;
CYCLOOXYGENASE/antagonists and inhibitor;
DEVOPROSTONE/antagonists and inhibitors
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To explore the anti - inflammatory mechanism of sinomenine, a monomer alkaloid from Caulis Sinomenii. [ Methods] In - vitro enzyme was applied to observe the effect of sinomenine on cyclooxygenase (COX) 1 and COX 2. [Results] Sinomenine at the concentration of 1 - 250 ?mol/L could inhibit the formation of PGE2 induced by COX 2 in a good dose - effect manner. [Conclusion] Sinomenine selectively inhibiting the activity of COX 2 may be the anti - inflammatory and anagesic mechanism of sinomenine with less gastrointestinal adverse effect.
