Effect of Electroacupuncture on NO, NOS and ET -1 Levels in Rats with Focal Cerebral Ischemia
- VernacularTitle:电针对局灶性脑缺血大鼠NO、NOS和ET-1的影响
- Author:
Nenggui XU
;
Wei YI
;
Xinsheng LAI
;
Rui JIN
- Publication Type:Journal Article
- Keywords:
CEREBRAL ISCHEMIA/acu - mox therapy;
NITRIC OXIDE;
NITRIC OXIDE SYTHASES;
ENDOTHELINS;
DISEASE MODELS, ANIMAL;
RATS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To study the effect of electroacupuncture on NO, NOS and ET - 1 levels in rats with focal cerebral ischemia (FCI). [Methods] Rat models with FCI were established by occlusion of unilateral middle cerebral artery. Twenty - two rats were allocated to three groups: Group A (mimic operation group), Group B (model group) and Group C (model rats treated with electroacupuncture). NO, NOS and ET - 1 levels in brain homogenate were measured by spectrophotometry and radioimmunoassay method respectively. [Results] Sixty minutes after modeling, NO, NOS and ET- 1 levels were increased and then decreased 10 minutes after acupuncturing Baihui (GV20) and Dazhui (GV14). [Conclusion] Electroacupuncture of Baihui (GV20) and Dazhui (GV14) can protect neuron from ischemic injury by decreasing the levels of NO and ET - 1 and inhibiting the activity of NOS.
