Effect of CBP on the level of blood lactic acid and 6 h lactic clearance rate in the patients with severe sepsis
- VernacularTitle:连续性血液净化对重症脓毒症患者血乳酸水平及6h乳酸清除率的影响
- Author:
Yuedong LI
;
Jingquan WANG
;
Min SHAO
- Publication Type:Journal Article
- Keywords:
severe sepsis;
blood lactic acid;
6h lactic clearance rate;
continuous blood purification;
prognosis
- From:
Acta Universitatis Medicinalis Anhui
2014;(2):251-253,257
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of continuous blood purification ( CBP) on the level of blood lactic acid and 6 h lactic clearance in the patients with severe sepsis. Methods 48 patients with severe sepsis were cho-sen in ICU, and they were randomly divided into two groups: control group ( n=20 ) and CBP group ( n=28 ) . Their arterial blood lactic acid level was tested on admission and was retested 6, 24, 48 and 72 h after treatment. The patients’6 h blood lactic clearance rate and the corresponding APACHEIIscore were calculated. The level of arterial blood lactic acid and the score of APACHE IIwere compared at different time. 6 h blood lactic clearance, the period of stay in ICU and the 28-days mortality were compared too. Results The level of lactic acid and the score of APACHE II after 24 h were lower in CBP group, and the period of stay in ICU was shorter in CBP group than that in control group at different time ( P<0.05 ) . 6 h blood lactic clearance was higher than that in control group (P<0.05). Moreover, the 28-days mortality had no significant difference in CBP group. Conclusion The CBP plays an important role in clearing the blood lactic acid and it can reduce the severity of the sepsis as well as shorten the period of stay in ICU.
