Comparison of Bioavailability of Qingxintong by Three Administration Routes
- VernacularTitle:青心酮三种给药途径的生物利用度比较研究
- Author:
Xuebing PANG
;
Guanming FU
;
Mingda ZUO
- Publication Type:Journal Article
- Keywords:
Qingxintong/pharmacokinetics;
@Qingxintong/analysis;
Chromatography,high pressure liquid
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
The in-vivo bioavailability of Qingxintong administrated by intramuscular injection, intravenous injection and gastric infusion was compared. Experimental results showed that Qingxintong was rapidly absorbed and excreted. The half-life time for absorption was 0.05 - 0.07 h and the half-life time for elimination was 0.14 - 0.29 h. The bioavailability of Qingxintong in the dose of 10 mg/kg by intramuscular injection or by intravenous injection was 94.71 %, and was 9.16% in the dose of 60 mg/kg by gastric infusion or in the dose of 10mg/kg by intramuscular injection.
