Screening of the Receiving Solution in Transdermal Absorption of Jiufen Spray
- VernacularTitle:九分喷雾剂透皮吸收接收液的筛选
- Author:
Yiqun SUN
;
Liling ZHOU
;
Xiaoyi CHEN
- Publication Type:Journal Article
- Keywords:
Jiufen spray/production & preparation;
Strychnine/analysis;
Absorption,transdermal;
Receiving solution
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To screen the receiving solution used to study the transdermal absorption of strychnine in Jiufen spray. Methods: With recovery,Q-T equation and transdermal speed constant as the parameters, the improved Franz-cell and the skin of SD rats were used to screen the receiving solution from saline, saline-alcohol (7∶3,v∶v), pH phosphate buffer solution-alcohol (88∶2,v∶v), pH 7.4 phosphate buffer containing 25% alcohol. Results: The comparison of the inter-day and intra-day recoveries,Q-T equation and transdermal speed constant showed that saline-alcohol(7∶3) was the best for the study. Conclusion: It is indicated that saline-alcohol(7∶3) was the best receiving solution for the transdermal absorption study of Jiufen spray.
