The Relationship between the Vimentin Expression and Lymph Node Metastasis and Parametrial Infiltration of Cervical Cancer
- VernacularTitle:宫颈癌组织Vimentin的表达与淋巴转移宫旁浸润的关系研究
- Author:
Huijin LIU
;
Qin XU
;
Jie WEI
;
Lihua YANG
- Publication Type:Journal Article
- Keywords:
Vimentin;
Cervical cancer;
Lymph node metastasis;
Parametrial infiltration
- From:
Journal of Kunming Medical University
2013;(10):122-124,128
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the Vimentin expression and lymph node metastasis of cervical cancer in order to explore the possibility of its predictive value on the lymph node metastasis and parametrial infiltration. Methods The expression of Vimentin in cervical cancer tissue microarray chip which contains 78 cases was evaluated by immunohistochemistry method to study the relationship between the expression and lymph node metastasis and parametrial infiltration of cervical cancer. Results The expression of vimentin in 78 cases of cervical cancer tissue was 30/78 (38.5%) .The expression of vimentin in cervical cancer was significantly related to lymph node metastasis and parametrial infiltration respectively. The expression of Vimentin in lymph node metastasis positive group was 15/31 (48.4%), which were significantly higher than that in lymph node metastasis negative group. The expression of Vimentin in parametrial infiltration positive group was 17/32 (53.1%), which were significantly higher than that in parametrial infiltration negative group ( <0.05) . Conclusions The expression of vimentin in cervical cancer tissue is correlated with lymph node metastasis and parametrial infiltration. It is an effective way to predict the lymph node metastasis and parametrial infiltration in cervical cancer patients.
