Study of association between neutrophil extracellular trap and interstitial lung disease in dermatomyositis patients
10.3760/cma.j.issn.1007-7480.2013.12.002
- VernacularTitle:中性粒细胞胞外网状陷阱与皮肌炎患者伴发的间质性肺病的相关性研究
- Author:
Sigong ZHANG
;
Xiaolan TIAN
;
Yinli ZHANG
;
Kanbo YANG
;
Hang ZHOU
;
Guochun WANG
;
Xin LU
- Publication Type:Journal Article
- Keywords:
Dermatomyositis;
Lung disease,interstitial;
Neutrophil extracellular traps
- From:
Chinese Journal of Rheumatology
2013;17(12):796-799,后插1
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study was focused on the association between neutrophil extracellular traps (NETs) and interstitial lung disease (ILD) in patients with dermatomyositis (DM).Methods Thirty six patients who satisfied the Bohan & Peter criteria for DM were recruited to this study,among whom 19 were complicated with ILD.Forty seven age and sex matched healthy Chinese volunteers were selected to be control subjects.The plasma samples of these patients were tested for the formation and degradation of NETs.Results DM plasma induced more NETs formation than control plasma did [(246±93) RFUs vs (192±53) RFUs,P=0.002].Compared to control,DM plasma exhibited a signficantry decreased ability to degrade NETs.Further mere,compared with DM patients without ILD (DMNL),DM patients with ILD (DML) could not degrade NETs completely [(83±13)％ vs (59±21)％,P＜0.01].All four DM patients with subacute ILD exhibited a significantly lower ability to degrade NETs than patients with chronic or asymptomatic ILD [(36±14)％ vs (65±19)％,P=0.0139].Conclusion These data show that more NETs formation is induced by plasma and DML fails to completely degrade NETs.These suggest that NETs may play a role in the pathogenesis of DM and DM-associated ILD.
