Expression of HSP27 and GPC-3 in primary hepatic cancer and its clinical implication
10.3969/j.issn.1671-8348.2013.25.007
- VernacularTitle:热休克蛋白-27与磷脂酰肌醇蛋白聚糖-3在原发性肝癌中的表达及意义
- Author:
Dong SHEN
;
Li LI
;
Jian GAO
- Publication Type:Journal Article
- Keywords:
heat shock protein-27;
glypican-3;
primary liver cancer;
immunohistochemistry
- From:
Chongqing Medicine
2013;(25):2969-2971,2974
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance of heat shock protein 27(HSP-27) and glypican-3(GPC-3) in diag-nosing primary hepatic cancer (PHC) and the clinicopathologic characteristics by detecting their expression in PHC .Methods Im-munohistochemistry was used to detect the expression of HSP-27 and GPC-3 in 32 cases of PHC tissue ,30 cases of live cirrhosis tissue ,25 cases of benign liver occupying tissue and 31 cases of hepatitis tissue .The relationship between their expression and the clinicopathologic features of PHC was analyzed .Results HSP-27 and GPC-3 were highly expressed in the PHC tissues ,the differ-ence had statistical significance compared with their expression levels in the liver cirrhosis tissues ,liver benign neoplasm tissues and hepatitis tissues(P<0 .05) .The expression of HSP-27 in the PHC tissues was correlated with the tumor pathological grade and the TNM stage ,while the expression of GPC-3 was not correlated with the tumor pathological grade and the TNM stage .Conclusion The high expression of HSP-27 and GPC-3 in the PHC tissue is closely related with the tumorigenesis ,progress ,metastasis of PHC ,which may become new pathological diagnosis markers of PHC .
