The relationship between chemokines and breast cancer
10.3969/j.issn.1007-3969.2013.08.010
- VernacularTitle:趋化因子与乳腺癌
- Author:
Zhouluo OU
- Publication Type:Journal Article
- Keywords:
Breast tumor;
Chemokines;
Atypical chemokine receptors
- From:China Oncology
2013;(8):618-623,636
- CountryChina
- Language:Chinese
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Abstract:
Many chemokines and chemokine receptors, such as CCL2 and CXCR4, participate in the growth, angiogenesis, distal metastasis of breast cancer. However, the recent failures in the clinical trials of some single target antagonists suggest that chemokine network in tumor microenvironment is really complicated. Obviously, multi-targets regulation strategy for chemokines is indispensable based on the polypharmacological principle in the future. Atypical chemokine receptors (ACR) as endogenous and physiological regulators, including Duffy antigen receptor for chemokines (DARC), D6 and ChemoCentryx chemokine receptor (CCX-CKR), may be the powerful candidates for this purpose.
