PKC?-CONTAINING NEURONS IN THE MEDULLARY AND SPINAL DORSAL HORNS PROJECTING TO THE MIDBRAIN PERIAQUEDUCTAL GRAY IN THE RAT
- VernacularTitle:大鼠延髓和脊髓背角的PKC?阳性神经元向中脑导水管周围灰质的投射
- Author:
Liping WU
;
Hui LI
;
Yunqing LI
;
Yuanqiang ZHANG
- Publication Type:Journal Article
- Keywords:
PKC?;
Medullary dorsal horn;
Spinal dorsal horn;
Periaqueductal gray;
Nociception;
Rat
- From:
Acta Anatomica Sinica
1953;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the projection of protein kinase C? isoform(PKC?)\|immunoreactive neurons from the medullary and spinal dorsal horns to the midbrain periaqueductal gray(PAG) in the rat. Methods By using fluoro\|gold(FG) retrograde tracing combined with immunofluorescence histochemical staining for PKC?. Results PKC?\|immunoreactive neurons were observed in laminae Ⅰ,Ⅱ,Ⅲ of the medullary and spinal dorsal horns and lateral spinal nucleus.After injecting FG into the PAG,FG retrogradely labeled neurons were also mainly found in laminae Ⅰ,Ⅱ,Ⅲ of the medullary and spinal dorsal horns and lateral spinal nucleus.Some of these FG\|labeled neurons in laminae Ⅰ,Ⅱ,Ⅲ of the medullary and spinal dorsal horns and lateral spinal nucleus exhibited PKC?\|immunoreactivities.Conclusion\ PKC?\|immunoreactive neurons in the medullary and spinal dorsal horns might be involved in the transmission of nociceptive information from the medullary and spinal dorsal horns to the PAG.\;[
