INFLUENCE OF PROGESTERONE ANTAGONIST-RU486 ON THE MACROPHAGES IN THE UTERI OF PREGNANT MICE AND ITS RELEVANCE TO PREGNANCY
- VernacularTitle:孕酮拮抗物RU486对妊娠小鼠子宫巨噬细胞的影响及与妊娠相关性的研究
- Author:
Xinghui TIAN
;
Zepei DENG
;
Xiuhui ZHONG
;
Zhanxiang ZHOU
- Publication Type:Journal Article
- Keywords:
Progesterone;
RU486;
Uterine macrophage;
Immunohistochemistry;
Mice
- From:
Acta Anatomica Sinica
1953;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective The experiment was conducted to explore the influence of progesterone antagonist\|RU486 on the macrophages in the uteri of pregnant mice and its relevance to pregnancy. Methods On day 4 and day10 of gestation, each mouse was subcutaneously injected with 150mg/L of RU486 (treatment group) or the same volume of saline (control group). The macrophages were immunohistochemically identified in the uterus 12, 24, 36?h after injection. Results Injection of RU486 on day 4 gestation had completely blocked the implantation of blastocysts. A large number of macrophages were found in the endometrium, myometrium and blood vessel layer 12～36?h after RU486 injection, which was significantly higher than that of the control groups ( P
