Experiment study on the safety of selective COX-2 inhibitor-celecoxib on gastric mucosa
- VernacularTitle:特异性环氧合酶-2抑制剂西乐葆胃黏膜安全性实验研究
- Author:
Junting LI
;
Zhaoshen LI
;
Xianbao ZHAN
- Publication Type:Journal Article
- Keywords:
Nonsteroidal anti-inflammatory drugs;
Celecoxib;
Gastric mucosal injuries;
Cyclooxygenase-1;
Cyclooxygenase-2
- From:
Chinese Journal of Digestion
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the gastric mucosa damage induced by celecoxib and conventional NSAIDs——indomethacin. Methods NSAIDs induced gastric mucosal damage model in rats was obtained by pouring indomethacin, celecoxib respectively (n=8); After gastric damage induced by means of 100% ethanol, celecoxib were administered by gastric gavage (n=8). Gastric mucosal 6-keto-PGF 1? ,TXB 2 level and lesion index (LI) were measured. Morphological changes of gastric mucosa were assessed under light and scanning electronic microscopy. Results Indomethacin caused obvious gastric damage (LI:13.38?2.06) and a marked reduction of 6-keto-PGF 1? ,TXB 2 level was observed (P
