Clinical study of sulindac in the treatment of sporadic colorectal adenomas
- VernacularTitle:舒林酸治疗散发性结直肠腺瘤的临床研究
- Author:
Yueqing QIAN
;
Yumin LU
;
Simao YE
- Publication Type:Journal Article
- Keywords:
Sulindac;
Colorectal adenoma;
Therapy
- From:
Chinese Journal of Digestion
2001;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of su lindac on sporadic colorectal adenomas. Methods Thirty-six patients diagnosed as sporadic colorect al adenomas colonoscopically and pathologically were randomly divided into t wo groups. The study group took 400 mg of sulindac daily and the control group w ere given placebo both for 4 months. Changes of number, size, figure and degree of atypia of adenomas were compared before and after treatment. Results Sixteen patients in each group finished the trial. In the study group, the average diameter of 59 adenomas before and after the treatment was (3.6?2.2) mm and (2.4?1.5) mm, respectively. The difference was statist ica lly significant (P0.05) nor were the changes in figure and degree of atypia of adenomas. Conclusions Sulindac is effective in the reduction of size and a typ ia degree of adenomas in patients with sporadic colorectal adenomas but the long term effects of sulindac in patients with sporadic colorectal adenomas should b e observed.
