The effects of arsenic trioxide on the expressions of cancerme tastasis associated genes
- VernacularTitle:三氧化二砷对人胃癌细胞转移相关基因表达的研究
- Author:
Tao LIANG
;
Tiefu LIU
;
Zhanjun MA
- Publication Type:Journal Article
- Keywords:
Arsenic trioxide (As_2O_3);
Gene expression
- From:
Chinese Journal of Digestion
2001;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To test the expression of five cancer metastasis associated genes indu ced by arsenic trioxide. Methods The expression of CD44,p53,nm23 ,H-r as and PCNA induced by arsenic trioxide were examined by immunohistochemistry me thod . Results Arsenic trioxide induced decrease of the expression of C D44,p 53 and PCNA in gastric cancer cells,and the expression of nm23 and H-ras were not changed by As_2O_3. Conclusions Arsenic trioxide inhibits the metastasis of gastric ca ncer cells through reducing the expression of cancer metastasis associated gene s.
