Diagnostic Value of HLA-B_(27) for Ankylosing Spondylitis
- VernacularTitle:HLA-B_(27)检测对强直性脊柱炎诊断的价值
- Author:
Yun SHEN
;
Yongjiang CHENG
;
Guangping LIU
- Publication Type:Journal Article
- Keywords:
HUMAN LEUCOCYTE ANTIGEN B 27/diagnostic use;
SPONDYLITIS, ANKYLOSING/diagnosis;
DIAGNOSTIC TEST,ROUTINE
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the diagnostic value for ankylosing spondylitis (AS).Methods Ninety-two patients with confirmed diagnosis of AS were allcated to Group A and 70 non-AS cases served as the control(Group B).Human leucocyte antigen B 27(HLA-B 27)was determined by micro-lymphocytoxicity test.Results The sensitivity and specificity of HLA-B 27 in diagnosing AS were 87.0% and 91.4% respectively.In a randomized human group,the morbidity rate of AS was 2.57% for those with HLA-B 27 being positive.In clinic,when the assumed morbidity rate of AS was 50%,the morbidity rate arrived at 91.01% for the cases of HLA-B 27 being positive.Conclusion HLA-B 27 is an important accessory diagnostic index for AS,but it can not be ued as a confirmed diagnostic index for AS.
