Protective Effect of Shengmai Injection on Adriamycin-induced Cytotoxicity of Diaphragm
- VernacularTitle:参麦注射液对阿霉素致膈肌毒性的保护作用
- Author:
Min GE
;
Sudong GUAN
- Publication Type:Journal Article
- Keywords:
Shengmai Injection/pharmacology;
Adriamycin;
Diaphragm/physiopathology;
Transdiaphramatical pressure(Pdi)/drug effects;
Diaphragm evoked potential(DEP)/drug effects;
Malondialdehyde/analysis;
Superoxide dismutase/analysis
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
To study the protective effect of Shengmai Injection on adriamycin-induced cytotoxity of diaphragm in rabbits. The rabbits were randomly allocated to three groups. The control group were treated with NS 2 ml?kg -1 for five days, adriamycin+NS group with NS 2ml?kg -1 for five days and then administered adriamycin 10 mg?kg -l and adriamycin + Shengmai Injection group with Shengmi Injection 2 ml?kg -l for five days and then administered adriamycin 10 mg?kg -1 . Twenty-four hours later, animals in the three groups were anaesthetized. Then the transdiaphragmatic pressure (Pdi) and diaphragm evoked potential(DEP) were measured, SOD activity and MDA content were tested and the ultrastructure of diaphragm cells was observed under electron microscope. Adriamycin could lower the Pdi and amplitude of DEP (P
