Comparative Study on Diuretic Effect and Acute Toxicity between Cortex Moriradicis with and without Rough Bark
- VernacularTitle:桑白皮除粗皮和未除粗皮利尿及急性毒性比较研究
- Author:
Wenjuan ZHANG
- Publication Type:Journal Article
- Keywords:
Cortex Moriradicis;
diuresis;
LD50
- From:
Chinese Traditional Patent Medicine
1992;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: Compare the effect of diuresis and acute toxicity between Cortex Moriradicis with and without rough bark. Methods: Accumulate and note the amount of urine produced by subjects rabbits by means of rabbit catheterization method, and calculate the LD50 on subjects mice by Bliss method. Results: No matter the decoction of Cortex Moriradicis with rough bark(ig 8.4g/kg) or without rough bark(ig.8.4g/kg) can increase greatly the amount of urine produced by rabbits( P 0.05). The LD50 of the decoction of Cortex Moriradicis with rough bark(ip) in the mice was 10.33?1.67g/kg while the LD50 of without rough bark(ip) was 8.39?1.11g/kg by Bliss method, showing significant difference. Conclusion: The effect on promoting the production of urination between Cortex Moriradicis with and without rough bark was no significant difference. The acute toxicity of Cortex Moriradicis without rough bark was more potent than that's of Cotex Moriradicis with rough bark.
