Psoriasiform dermatosis in HLA-B2704 transgenic mice
- VernacularTitle:HLA-B2704转基因小鼠的银屑病样皮肤病
- Author:
Dong WANG
;
Houshan L
;
Haiming DING
- Publication Type:Journal Article
- Keywords:
Arthritis,psoriatic;
HLA B27 antigen;
Mice,transgenic
- From:
Chinese Journal of Rheumatology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To confirm the role of HLA B2704 in the pathogenesis of psoriasiform dermatosis by investigating the phenotype of skin diseases in HLA B2704 transgenic mice.Methods The transgenic positive mice were screened and identified by PCR,dot blot and Southern blot hybridization.HE and Immunohistochemistry staining of the diseased mice skin were performed to detect the pathological changes and expression of HLA B2704.Results Six transgenic positive mice developed obvious psoriasiform dermatosis.Histologically,the skin was massively thickened by psoriasiform hyperplasia and keratinization.HLA B2704 antigen was highly expressed on the cell surface.Conclusion HLA B2704 heavy chain can induce the psoriasiform dermatosis in the transgenic mice.
