Disturbance of bone mineralization induced by continuous administration of etidronate disodium in ovariectomized rats
- VernacularTitle:二膦酸盐长期服用可造成去势大鼠成骨矿化障碍
- Author:
Shunlu YU
;
Weisheng YE
;
Jin XU
- Publication Type:Journal Article
- Keywords:
Bisphosphonates;
Ovariectomy;
Rats;
Bone histomorphometry
- From:
Chinese Journal of Rheumatology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the different effects of continuous and intermittent administration of etidronate disodium in bone formation for osteoporosis.Methods Fifty 3 month old virgin female rats weighing (200?10) g were divided equally into 5 groups:pseudo ovariectomized group (group A), ovariectomized group (group B),estrogen replacement group (group C),intermittent etidronate disodium administered group (group D) and continuous etidronate disodium administered group (group E).Postoperative 30 days,group C was given nylostricl 0 1 mg?kg -1 ?d -1 for 100 d;group D was intermittently given etrdonate disodium 10 mg?kg -1 ?d -1 for 14 d and after 35 d interval the drugs were given once more;group E was continuously given etrdonate disodium 10 mg?kg -1 ?d -1 for 100 d.All rats were given drugs orally and were killed at day 100.The bone density,bone mineral content and bone histomorphometrical study were made.Results The average of BMD values of group A,B,C,D,E were [(47 6?2 7),(31 6?7 0),(38 2?4 9),(41 8?8 4),and (29 4?9 4) ( [AKx-]?s ),mg/cm 2] respectively.The value of group E was significant lower than that of group A and group D ( P
