Long-term infection with Helicobacter pylori in Mongolian gerbils
- VernacularTitle:幽门螺杆菌长期感染蒙古沙土鼠腺胃模型的建立及评价
- Author:
Yongli YAO
;
Wandai ZHANG
;
Bo XU
- Publication Type:Journal Article
- Keywords:
Helicobacter pylori;
Gastric neoplasm;
Mongolian gerbil
- From:
Chinese Journal of Digestion
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate pathological chan ges in stomach during long-term Helicobacter pylori (H.pylori) infection in Mongolian gerbil model. Methods Mongolian gerbils were inoculated with H.pylori NCTC 11637. Results Mongolian gerbil model of long-term H.pylori infecti on was successfully established. It was shown that H.pylori could induce the pro cess progressing from normal gastric mucosa to chronic gastritis, glandular atro phy, intestinal metaplasis, and atypical hyperplasia, though no adenocarcinoma w as found in the experimental animals. Conclusions H. pylori NC TC 11637 can colonize easily in the glandular stomach mucosa of Mongolian gerbi ls. The stability of this model is excellent, and th e histological chang es are similar to those of humans with H. pylori infection.
