Comparison on Pharmacodynamics Effects between Different Extracts of Fructus Trichosanthis and Bulbus Allii Macrostemi
- VernacularTitle:不同制备工艺的瓜蒌薤白提取物药效学比较
- Author:
Hong CAO
;
Siwei CHEN
;
Minwei WANG
;
Naili WANG
- Publication Type:Journal Article
- Keywords:
fructus trichosanthis;
bulbus allii macrostemi;
coronary blood flow;
platelet aggregation;
myocardial hypoxia
- From:
Chinese Traditional Patent Medicine
1992;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To compare pharmacodynamics properties between the extracts of Fructus Trichosanthis and Bulbus allii(water extraction, WE; ethanol extraction, EE). Methods: To establish model of normobaric hypoxia in mice with isoprenaline; determinated the coronary blood flow of isolated guinea pig heart and rabbits platelet aggregation induced by ADP in vitro. Results: EE was more effective than WE on the prolongation of survival time of mice; EE and WE significantly increased coronary blood flow and inhibited platelet aggregation at the same dose. Conclusion: At the same dose, the effect of EE is superior to WE.
