The changes of serum levels of interleukin-6 and interleukin-8 in pregnant women with systemic lupus erythematosus
- VernacularTitle:妊娠合并系统性红斑狼疮患者血清白细胞介素6、8检测的临床意义
- Author:
Yu SU
;
Suying HONG
;
Yu ZHANG
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus, systemic;
Interleukin-6;
Interleukin-8;
Pregnancy complications
- From:
Chinese Journal of Obstetrics and Gynecology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the changes of serum levels of interleukin-6(IL-6) and interleukin-8 (IL-8) in pregnant women with stationary phase systemic lupus erythematosus (SLE). Methods Enzyme-linked immunosorbent assay (ELISA) was used to measure serum IL-6 and IL-8 from 14 pregnant women with stationary phase SLE (SLE group), 12 normal pregnant women (normal pregnant group) and 12 normal non-pregnant women (group normal non-pregnant). The later two groups are set as controls. Results The IL-6, IL-8 levels in group SLE patients are (20.31?5.70) ng/L and (48.80?9.17) ng/L, significantly higher than those in normal pregnant group [IL-6, IL-8 levels are (8.40?2.49) ng/L and (21.15?5.21) ng/L, respectively, P 0.05). Conclusion Serum levels of IL-6, IL-8 may be helpful to monitor the progress of SLE during pregnancy.
