Study on endothelial cell injury in women with pregnancy induced hypertension
- VernacularTitle:妊娠高血压综合征患者内皮细胞损伤的研究
- Author:
Weihong ZHAO
;
Lijun CHEN
;
Linhong WANG
- Publication Type:Journal Article
- Keywords:
Pregnancy complications, cardiovascular;
Hypertension;
Endothelium, vascular;
Apoptosis
- From:
Chinese Journal of Obstetrics and Gynecology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the mechanisms of endothelial cell injury in women with pregnancy induced hypertension (PIH). Methods Human umbilical endothelial cells were cultured in the serum from 10 women with severe PIH and 10 normal pregnant women, and co-cultured with neutrophils or not for 48hrs. The morphology and cell cycles were studied. Results Without neutrophils, no apoptotic cells were observed, while neutrophils were added, apoptotic cells were obviously detected. The percentage of apoptotic cells in PIH was more than that in non-PIH. The percentage of cells in G 2/M phase decreased in all the groups, but there were no significant differences among them. Conclusions Endothelial cells were injured indirectly in PIH patients. Activated neutrophils induced apoptosis might be one of the answers.
