FHIT alteration in human esophageal, gastric and colorectal carcinomas
- VernacularTitle:FHIT基因异常与消化道恶性肿瘤
- Author:
Honggang YU
;
Laibao SUN
;
Baoping YU
- Publication Type:Journal Article
- Keywords:
Digestive tract;
Tumor;
fragile histidine triad (FHIT) gene
- From:
Chinese Journal of Digestion
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the status of fragile histidine triad (FHIT) gene in human esophageal, gastric and colorectal carcinomas. Methods Ninety six samples of digestive tract cancer (including 21 esophageal carcinomas, 43 gastric carcinomas and 32 colorectal carcinomas) tissues and their adjacent non carcinoma tissues and 18 samples of normal tissue were examined by nested RT PCR for FHIT gene alteration. Results Aberrant transcripts were observed in 33.3% esophageal cancers, 51.7% gastric cancers and 31.3% colorectal cancers. In the adjacent esophageal,gastric and colorectal non carcinoma tissues the rate of aberrant transcripts were 4.8%,20.9% and 9.4%, respectively ( P
