Regulatory effects of mifepristone and progesterone on the secretion of interleukin-6 by cultured eutopic and ectopic endometrial cells
- VernacularTitle:米非司酮和孕酮对子宫内膜异位症患者子宫内膜白细胞介素6分泌的影响
- Author:
Jing LU
;
Jing JIANG
;
Ruifang WU
- Publication Type:Journal Article
- Keywords:
Endometriosis;
Interleukin 6;
Mifepristone;
Progesterone
- From:
Chinese Journal of Obstetrics and Gynecology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the regulatory effects of mifepristone and progesterone on the secretion of interleukin 6 (IL 6) by endometrial and endometriosis cells in vitro. Methods Primary cultures of eutopic and ectopic endometrial cells from 9 cases of endometriosis were exposed to mifepristone (10 -6 mol/L, 10 -4 mol/L) and progesterone (1?10 -7 mol/L, 1?10 -5 mol/L) respectively. IL 6 secretion was analyzed in the culture medium by enzyme linked immunosorbent assay (ELISA). Results Mifepristone inhibited the IL 6 secretion of ectopic endometrial cells, with the concentrations of IL 6 was (1 914 33?799 28) ?g/L in the 1?10 -6 mol/L group ( P 0 05). Conclusion The inhibitory effects on the secretion of IL 6 by ectopic and (or) eutopic endometrium may provide one of the cellular therapeutic mechanisms of mifepristone and progesterone on endometriosis.
