Expression of vascular endothelial growth factor in treatment process of rabbit arthritis model with corticosteroids
- VernacularTitle:血管内皮细胞生长因子在激素治疗兔关节炎模型过程中的基因表达
- Author:
Yonggang WU
;
Junchang CHEN
;
Kunzheng WANG
- Publication Type:Journal Article
- Keywords:
Arthritis;
Reverse transcriptase polymerase chain reaction;
Endothelial growth factors
- From:
Chinese Journal of Rheumatology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the expression of vascular endothelial growth factor (VEGF) in synovial tissue during treatment of rabbit arthritis model with corticosteroids and explore its mechanism.Methods The expression and alteration of VEGF in different periods of treatment process of rabbit arthritis model with corticosteroids (after 1 h ,24 h,3,7,14,21 and 28 d treatment with lipopolysaccharide),were investigated by reverse transcript polymerase chain reaction (RT PCR).Results There were different expressive degrees of VEGF in synovial tissue during each period of the process of rabbit arthritis model by corticosteroid treatment and the expressive degree of VEGF had been strongly inhibited by corticosteroids.Conclusion It is indicated that corticosteroids decrease inflammatory reaction of arthritis by inhibiting the expression of VEGF.
