Therapeutic effect of mycophenolate mofetil on severe systemic lupus erythematosus patients
- VernacularTitle:霉酚酸酯治疗重症系统性红斑狼疮的临床研究
- Author:
Zhizhong YE
;
Xiangguang XU
;
Junhan ZHUANG
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus,systemic;
Cyclophosphamide;
Mycophenolate mofetil
- From:
Chinese Journal of Rheumatology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the therapeutic effects and side effects of MMF on severe SLE patients compared with CTX.Method All 106 severe SLE patients were randomly allocated to 2 groups:MMF treatment group (53 patients):1 5 g/d for 3 months,1 0 g/d for following 3 months,and then 0 5～0 75 g/d;IVCTX treatment group:0 75 g/m 2 per month for 6～12 months.Prednisone was used in all patients.Clinical and laboratory parameters including SLE DAI,Hb,platelet,urine protein,albumin,SCr,aCL,ANA and anti dsDNA were observed.Results After 3 month treatment,all clinical and laboratory parameters were significantly improved in MMF group,while only partial parameters were improved in CTX group.Hb and platelet increased and urine protein and anti dsDNA decreased faster in MMF group than in CTX group.At month 6 the clinical and laboratory parameters improved significantly in both groups ( P
