Actions of Immature Orange Fruit and Dried Tangerine Peel on the Tension of Isolated Aortic Muscle Strips
- VernacularTitle:枳实和陈皮对兔离体主动脉平滑肌条作用机理探讨
- Author:
Hongfang LI
;
Danming LI
;
Songyi QU
- Publication Type:Journal Article
- Keywords:
immature orange fruit and dried tangerine peel;
aortic smooth muscle string;
tension
- From:
Chinese Traditional Patent Medicine
1992;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the effects of immature orange fruit(IOF) and dried tangerine peel(DTP) on the resting tension of isolated aortic muscle strips in rabbits and their mechanisms. Methods: The organ-bath was used to observe the response of aortic strip to IOF and DTP. Results: IOF and DTP dose-dependently increased the tension of aortic strip, and the action of IOF was more significant than that of the same concentration DTP. 10 -7 mol/L phentolamine, 10 -5 mol/L verapamil or incubation with Ca 2+ -free Krebs solution could block the effects of IOF and DTP partly, but 10 -6 mol/L diphenhydramine could not. In endothelium-removed aortic strips, the effects of IOF and DTP decreased after treatment with 10 -7 mol/L atropine. Conclusions: IOF and DTP can contract vascular smooth muscle, which probably contribute to ? adrenergic receptor, cholinergic M receptor on membrane of vascular smooth muscle partly, and is dependent Ca 2+ influx through verapamil-sensitive Ca 2+ channels, but is not related to H 1 histamine receptor.
