Comparison of Effects of Xiaoyu Tablets and its Constituents on Endothelin-1 and Nitric Oxide in Atherosclerotic Rabbits
- VernacularTitle:消瘀片及其组分对粥样硬化兔ET-1体内和NO影响比较研究
- Author:
Meilin XIE
;
Zhenlun GU
;
Lujia ZHU
;
Qun LU
- Publication Type:Journal Article
- Keywords:
Xiaoyu Tablets;
Radix salviae miltiorrhizae;
Fructus Crataegi;
endothelin-1;
nitric oxide
- From:
Chinese Traditional Patent Medicine
1992;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To determine the rationality of prescription of Xiaoyu tablets. Methods: The effects of Xiaoyu tablets and its single constituents on endothelin-1(ET-1) and nitric oxide(NO) in atherosclerotic rabbits were observed. Results: Xiaoyu tablets showed stronger actions than its single constituents (extract of radix salviae miltiorrhizae or fructus crataegi) in decreasing the contents of ET-1 in plasma and atherosclerotic vessel wall and increasing the contents of NO in serum and atherosclerotic vessel wall. Conclusion: There was the obvious synergism on reduction of ET-1 and elevation of NO in atheroscleerotic rabbits when both extracts of the Chinese herbal medicines were simultaneously used.
