A novel antiapoptosis gene, survivin, bcl-2, p53 expression in cervical carcinomas
- VernacularTitle:凋亡相关基因survivin在子宫颈癌组织中的表达及其与bcl-2、p53基因表达相关性的初步研究
- Author:
Mei WANG
;
Bing WANG
;
Xiaoli WANG
- Publication Type:Journal Article
- Keywords:
Genes;
Genes, bcl 2;
Genes, p53;
Cervix neoplasms;
Immunohistochemistry
- From:
Chinese Journal of Obstetrics and Gynecology
2000;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of a novel inhibitor gene of apoptosis, survivin, in cervical carcinoma and its relationship with the expression of bcl 2, p53 genes Methods Using streptavidin biotin peroxidase (SP) method, we examined the expression of survivin, bcl 2 and p53 genes in 10 normal cervical tissues and 59 cervical carcinoma tissues Results Survivin was expressed in 41 of 59 (69 5%) cases of cervical carcinomas In contrast, normal cervical epithelium did not express survivin Overexpression of survivin was related to the tumor grade and clinical stage Survivin positive cases were strongly associated with bcl 2 expression (36/45, 80 0% versus 5 of 14 cases, P
