Effect of thalidomide on the expression of VEGF mRNA in human breast cancer cell lines
- VernacularTitle:沙立度胺对乳腺癌细胞血管内皮生长因子表达的影响
- Author:
Shuqin LI
;
Yenxia JI
;
Zhiyong YANG
;
Haiyan LI
;
Zhenjun ZHANG
;
Jungang JIA
;
Lianggang WAN
- Publication Type:Journal Article
- Keywords:
Breast neoplasm;
Thalidomide;
Vascular endothelial growth factor;
Cell lines
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(7):1057-1058,倒插1
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the effects of thalidomide on VEGF mRNA level in human breast cancer cell lines. Methods Breast cancer cells were treated with thalidomide for 24～72h, RT-PCR was uced to detect the level of VEGF mRNA expression. Results When the concentration of drug is 50μg/L,thalidomide strongly inhibited the level of VEGF mRNA expression. Conclusion Within certain concentration range of thalidomide can inhibit the level of VEGF mRNA expression in breast cancer cell.
