Expression of human leucocyte antigen in ectopic endometrial tissue of endometriosis
- VernacularTitle:异位子宫内膜组织中人类白细胞抗原的表达
- Author:
Hong XU
;
Wen DI
;
Defu CHEN
- Publication Type:Journal Article
- Keywords:
Endometriosis;
HLA antigens
- From:
Chinese Journal of Obstetrics and Gynecology
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the human leucocyte antigen (HLA) expression of ectopic endometrial epithelial cells in cases with endometriosis and its role in pathogenesis of endometriosis Methods By immunohistochemical analysis,HLA expression was observed in ectopic endometrial epithelial cells of 25 endometriosis patients Ectopic endometrial cells were cultured in vitro successfully and the expression of HLA were analyzed by flow cytometry in 10 out of the 25 patients Eutopic endometrium of 15 normal women were taken as control Results (1)Expression of HLA class Ⅰ molecule on ectopic endometrial epithelial cells of endometriosis measured by the immunohistochemical analysis was lower than those of controls, (4 0?0 5) score and (1 2?0 8) score respectively So was the expression rate by flow cytometry in vitro culture (63 38?11 88)% and (5 27? 2 88)% respectively ( P
