Detection of sICAM-1,sVCAM-1,TNF-?,TNFR-Ⅰ and TNFR-Ⅱ in vasculitis
- VernacularTitle:血管炎患者sICAM-1 sVCAM-1 TNF-?TNFR-Ⅰ与TNFR-Ⅱ的测定及其意义
- Author:
Ning LI
;
Houheng SU
;
Bo CHEN
- Publication Type:Journal Article
- Keywords:
Vasculitis;
Tumor necrosis factor;
Receptors,tumor necrosis factor;
Intercellular adhesion molecule 1;
Vascular cell adhesion molecule 1
- From:
Chinese Journal of Rheumatology
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between sICAM 1,sVCAM 1,TNF ?,TNFR Ⅰ,TNFR Ⅱ and pathogenesis of vasculitis.Method The serum levels of TNF ?,TNFR Ⅰ,TNFR Ⅱ,sICAM 1 and sVCAM 1 were detected by ELISA and their levels between patients with vasculitis and controls were compared.Results Compared with the controls,the serum level of TNF ? was lower,the levels of TNFR Ⅰ,sICAM 1 and sVCAM 1 were higher in the patients with vasculitis,and there was no difference of TNFR Ⅱ between the two groups.Conclusion The low level of TNF ? suggests that this factor may not play a role in these patients,or its role was counteracted by its receptors—sTNFR,whose level was higher in patients with vasculitis.sICAM 1 and sVCAM 1 may play a significant role in the pathogenesis of vasculitis.
