Efficacy and the prognostic factors of postoperative radiotherapy in malignant gliomas
10.3760/cma.j.issn.1006-9801.2010.08.014
- VernacularTitle:恶性胶质瘤术后放疗的疗效及预后因素分析
- Author:
Jianbo MA
;
Jian SHI
;
Bin JI
;
Zhiming CHEN
- Publication Type:Journal Article
- Keywords:
Brain;
Glioma;
Radiotherapy;
Prognosis
- From:
Cancer Research and Clinic
2010;22(8):547-549,553
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical effects and prognostic factors of postoperative radiotherapy for malignant gliomas. Methods From June 1998 to October 2007, seventy-eight cases of malignant gliomas patients were treated with radiotherapy after surgery, including -28 cases received whole brain radiotherapy, 34 cases local field irradiation and 16 cases three-dimensional conformal radiotherapy. Thirty-one cases received chemotherapy which included semustine, semustine plus teniposide and temozolomide. Kaplan-Meier survival analysis and COX regression analysis were used to analyze the prognostic factors. Results The median survival time and 1-, 3-, 5-year survival rate were 16 months, 65.4 %, 32.8 % and 17.9 % for all patients, respectively; 24 months, 72.7 %, 41.5 % and 22.8% for grade 1 patients; 11 months, 47.8 %, 10.9 % and 5.4 % for grade IV patients. Univariate analysis showed the age, Karnofsky, pathologic grade, surgical approach and the time from surgery to radiotherapy were significantly correlated with the survival time (P <0.05). Karnofsky (P =0.000), pathologic grade (P =0.004) and age (P =0.011) were independent prognostic factors in the multivariate analysis. Conclusion Prognosis of the patients with Karnofsky ≥70, age < 50 years and grade Ⅲ is better in malignant gliomas. Postoperative radiotherapy combined with chemotherapy may prolong the survival time.
